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Understanding Mycotoxins and Predicting Risk in a Changing Climate

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According to NASA, the Earth’s average temperature has increased by 1.9 degrees Fahrenheit since modern recordkeeping began in 1880.

Average global temperatures in the last four years have been the hottest years on record. There have also been more high temperature extremes with many areas experiencing droughts.

Some regions, however, experience heavier rainfall as a result of climate change. The United States has seen heavier precipitation and more flooding events, as noted in the graph below from the U.S. Global Change Research Program.

The map below shows the percent increase of heavy precipitation in US regions from 1958 to 2012:

These changing conditions can increase the risk of mycotoxins in food and feed, which has both health and economic implications. It is something farmers, grain inspectors, buyers, and merchandisers need to be aware of. In this article, we give you an overview of the situation and provide you with some useful tools to help manage this risk.

What are Mycotoxins?

There are over 200,000 species of fungi that include yeasts from which we make bread and beer, as well as the mushrooms we enjoy as food. Some fungi produce compounds used to make antibiotics and pharmaceutical drugs. These same fungi, as well as others, can also produce secondary metabolites that are poisonous to humans and animals. The poisonous compounds produced by these various fungi are referred to as “mycotoxins”.

The word “mycotoxin” is derived from the word “myco” (relating to fungi) and “toxins”. It was coined in the 1960s when 100,000 turkeys in England died from what was then called turkey X disease. Eventually, it was found that these deaths were linked by contaminated peanut meal. The turkeys’ autopsies revealed damaged livers and tumors.

The earliest recognized mycotoxin outbreak was known as St. Anthony’s Fire, which was widespread in Europe during the Middle Ages. Paintings and writings depict people suffering from gangrene, lost appendages, and hallucinations brought about by the outbreak.

We now know that different types of mycotoxins target different body systems and organs and that some mycotoxins can affect multiple body systems. Most mycotoxins suppress the immune system, making it easier for bacterial infections and diseases to occur.  In animal studies, the young are more susceptible to mycotoxins than adults.

Aspergillus, Fusarium, and Penicillium are the primary species of disease-causing fungi. Mycotoxin contamination typically starts during the growing season, and increases during harvest, drying, and storage, especially when environmental conditions are ripe.

Foods made from contaminated crops are not the only risk factor. Animals that have consumed contaminated feed can also pass on these mycotoxins and their toxic metabolites, which can be found in meat, milk products, and eggs.

Unfortunately, mycotoxins are not easily removed or destroyed during food processing. For this reason, many food processors will not accept feed containing mycotoxins into their facilities. Mycotoxins affect 25% of the world’s crops, costing US agriculture $1 billion/year. This problem will likely get worse with a changing climate.

Let’s take a look at some of these mycotoxins in more detail, before discussing the impact climate change may have on mycotoxin contamination.

Common Disease-Causing Mycotoxins

Most mycotoxins impact the immune system. Certain body systems and organs are impacted more so than others, depending on the mycotoxin ingested. Fungi species don’t all respond to the same environmental conditions or infect the same type of crop. More than one fungal species can produce the same type of mycotoxin.

Aflatoxins

Aflatoxins are one of the primary mycotoxins impacting human and animal health. They are produced mainly by Aspergillus flavus, A. parasiticus, and A. nomius. Aspergillus thrives in warm, humid, and subtropical regions. High temperatures and drought conditions cause plant stress, which increases fungal colonization.

There are over 20 known aflatoxins, but the primary ones are B1, B2, G1, G2, and M1. Aflatoxins can be present in both plant and animal foods such as milk, milk products, meat, and eggs if animals have eaten contaminated feed.

Aflatoxins are carcinogenic (cancer-causing) and mutagenic (DNA altering). They can cause liver damage, tumors, birth defects, chronic disease, and even sudden death.

Primary crops affected: Peanut, corn, cotton, rice, tree nuts, figs, and copra

Vomitoxin

Vomitoxin (called deoxynivalenol or DON for short) is another common occurring mycotoxin and is in the trichothecene family. It is produced by Fusarium graminearum and F. verticillioides.

Fusarium prefers an environment that is wet and cool. Infection can happen on the field between flowering time to maturity, as well as during storage. DON can cause scab or blight disease in grains. Even visibly healthy-looking grain, however, can still contain a high level of DON. Vomitoxin can be found in flour, bread, beer, and baby food, as well as in liver, milk, and eggs.

DON exposure can cause vomiting, taste aversions, and even anorexia. It can make the digestive system more sensitive. Pigs are particularly sensitive to DON. It’s been shown to cause kidney disease in mice.

Primary crops affected:  Corn, wheat, barley, and sorghum

Fumonisin

Fumonisin is produced by Fusarium verticillioides. It can cause major health problems in horses and pigs. It may also be involved with human esophageal cancer, as well as diseases involving the brain, lungs, liver, and kidneys.

Primary crop affected: Corn

Zearalenone

Zearalenone is an estrogenic mycotoxin produced by Fusarium graminearum. It can co-occur with DON.

In humans, zearalenone impacts the reproductive system and can cause early puberty in 7 and 8-year-old children, as well as premature breast development and breast enlargement. It may be involved in cervical cancer. It has been found to cause an enlarged uterus in mice.

Pigs are particularly sensitive to zearalenone and may experience vulvovaginitis, abortion, and a wasting away of ovaries and testicles.

Primary crop affected: Corn, barley, rice, oats, rye, sorghum, soya, wheat

Ochratoxin

Ochratoxin can cause significant disease in animals. It is produced by both Aspergillus and Penicillium and can target the brain, kidneys, and liver. It can be found in pig and poultry meats.

Primary crops affected:  Wheat, barley, peanuts and cocoa

T-2

T-2 is a toxin produced by Fusarium. It is found in European grains more so than in US grains. T-2 can be lethal, as it impacts protein synthesis and cell replication. It is believed that T-2 was responsible for killing almost 100,000 people in Russia in the 1940s. This may have been due to a delayed harvest because of World War II.

Primary crop affected: Corn, barley, wheat, oats, rye

How Climate Change Impacts Mycotoxin Contamination

Aflatoxin contamination is more likely to happen in drought conditions when there is below average rainfall and higher than average temperatures. This was seen in the US Corn Belt during the 2012 drought. Not only did farmers see reduced yields, but they also found increased levels of aflatoxin, resulting in food recalls. Similar outbreaks occurred in 2003 and 2005 in Iowa, which led the Department of Agriculture to petition the FDA to allow corn blending to be set at lower concentrations.

Wet and warm conditions, on the other hand, can cause an increase in DON contamination.  The high relative humidity is ideal for Fusarium growth. This is especially problematic with wheat just before and during flowering and in corn during silking. In 2016, wet conditions in the US Corn Belt caused a vomitoxin outbreak, causing feed companies to purchase corn from South America.

Tools and Resources to Manage Mycotoxin Control in Changing Climates

While there are many conditions and agricultural practices that can be controlled, such as choosing more resistant cultivars, rotating crops, fungicides, insect and rodent control, reducing mechanical damage, etc., there are things out of our control such as flooding, hot weather, and drought. But, with the right forecasting tools and information, some things can be done to minimize mycotoxin exposure.

Below are some excellent tools and resources.

The FDA establishes action levels to help control mycotoxins in the United States and help keep contaminated agricultural products from entering the food chain. There are legal limits to mycotoxin levels in our food that take into consideration tolerable daily intakes for both humans and animals.

As the climate continues to change, farmers, grain inspectors, grain buyers, grain merchandisers, and food processors will need to take a more proactive approach in controlling this significant health threat, as this problem will impact the safety of our global food supply.

About Charm Sciences

Established in 1978 in Greater Boston, Charm Sciences helps protect consumers, manufacturers, and global brands from a variety of issues through the development of food safety, water quality, and environmental diagnostics tests and equipment. Selling directly and through its network of distributors, Charm’s products serve the dairy, feed and grain, food and beverage, water, healthcare, environmental, and industrial markets in more than 100 countries around the globe.

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